赵大克，男， 博士，1983年9月生，山东省聊城市人。入选云南省“万人计划”青年拔尖人才。现任植物学与动物学系教授，硕士生/博士生导师。
主主要从事植物次生代谢产物功能与机制研究。先后主持国家自然科学基金项目3项，云南省基础研究重点项目1、云南省高层次引进人才项目1项（二等资助）、云南省第三批博士后资助1项（一等资助）等十余项。发表SCI刊物上发表40余篇，其中，中科院一区论文15篇，Cell Press旗下期刊4篇，ESI高被引论文3篇，单篇它引次数最高为338次。主编出版专著1部。获云南省自然科学三等奖1项（2021）、红云园丁奖1项（2021），入选尊龙凯时生态学科青年人才培养计划（2022）。
以具有显著镇痛抗炎活性成药成分二萜生物碱（diterpenoid alkaloids）、生物演化的关键标志性分子褪黑素（melatonin）为研究对象，致力于挖掘和解析目标产物的生物合成基因及催化机制、探究其生物学功能及进化机制，并通过代谢工程及种质资源创新等手段高效获取目标产物。主要发现如下：
（1）系统开展了乌头属植物二萜生物碱的分离与鉴定工作，获得二萜生物碱230余个，其中新化合物41个，贡献了全球近十年新发现二萜生物碱总数的11%，提出了二萜生物碱骨架分类新系统；在国际上率先探索了二萜生物碱生物合成与起源与演化机制，揭示了二萜生物碱合成的遗传基础，在国际二萜生物碱研究领域产生了重要影响。
（2）聚焦于褪黑素这一极其古老分子的合成路径起源与进化，创新性的提出了褪黑素生物合成基因起源于原核生物及古菌，并通过内共生途径进入真核细胞的新观点；将褪黑素与植物登陆这一关键历史生态事件相关联，首次揭示了褪黑素在植物早期登陆及陆生生境适应性进化中的关键作用，深化来植物次生代谢产物在生物适应性进化机制的认知。
联系方式：
E-mail: zhaodk2012@cqlty.com
学历
l 2003.09－2006.07: 云南农业大学园林系，农学学士
l 2006.09－2009.07: 云南农业大学，园林植物与观赏园艺专业，农学硕士
l 2009.09－2012.07：中科院昆明植物所，植物学专业，理学博士
近十年主持或承担的科研项目
l 2016年-2019年：国家基金委地区项目，乌头剧毒特性关键BAHD酰基转移酶基因的鉴定与功能研究，项目负责人，经费45万元
l 2018年-2019年：云南省人社厅，云南省第三批博士后资助（一等资助）项目负责人，经费10万元
l 2021年-2023年：国家基金委地区项目，“生态专一型”兰科菌根真菌促进金沙江石斛种子萌发机理研究，项目负责人，经费40万元
l 2021年-2023年：云南省委组织部人才项目，云南省“万人计划”青年拔尖人才，项目负责人，经费50万元
l 2021年-2026年：云南省人社厅，2020年云南省引进高层次人才工作经费，二等资助，项目负责人，经费7万元
l 2021年-2023年：云南省自然科学基金重点项目，具有重要生物活性的二萜生物碱合成途径中初始骨架的生物合成，经费50万元
l 2022年-2025年：尊龙凯时，尊龙凯时生态学科青年人才，项目负责人，经费60万元
l 2023年-2026年：国家基金委面上项目，毛茛科产二萜生物碱性状的发生与创新：基于贝壳杉烯氧化酶基因（KO）的功能歧化，项目负责人，经费54万元
l 2023年-2026年：国家基金委面上项目，毛茛科产二萜生物碱性状的发生与创新：基于贝壳杉烯氧化酶基因（KO）的功能歧化，项目负责人，经费54万元
社会兼职
l 《Melatonin Research》编委，2023-。
获奖情况
l 2021年获云南省自然科学三等奖(排名第1)：云南十一种药用乌头属植物活性成分二萜生物碱的发现及活性评价
l 2021年获红云园丁奖(排名第1)：“红云园丁奖”优秀教师
参加编写的主要论著：
1. 刘琴, 赵大克, 艾洪莲著. 2023年. 论著名称: 中国少数民族医药资源与保护研究丛书—傣医药, 湖北科技出版社.
近十年发表主要学术论文：
1. Zhao D.K., Mou, Z.M.,Zhao, E.Q., Bai, J.M., Zhang, X., Yuan, Z.H., Wang, R.B., Wang, Q.X., Jacquemyn, H., Ning, C. Phorophyte preference of an epiphytic orchid (Dendrobium wangliangii) is independent of orchid mycorrhizal fungi that promote seed germination. Journal of Ecology, doi.org/10.1111/1365-2745.14298, 2024.(封面论文；中科院一区；IF=5.5；Top期刊)
2. Zhao, D.K., Mou, Z.M., Ruan, Y.L. Orchids acquire fungal carbon for seed germination: Pathways and players. Trends in Plant Science, doi.org/10.1016/j.tplants.2024.02.001, 2024. (封面论文；中科院一区；IF=20.5；Top期刊)
3. Shen, Y., Liang, W.J., Shi, Y.N., Kennelly, E.J.*, Zhao, D.K.* Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids. Natural Product Reports 37, 763-796, 2020. (封面论文；中科院一区；IF=11.9；Top期刊)
4. Zhao, D.K.*, Wang, H.P., Chen, S.Y., Yu, D.Q., Reiter, J.R.* Phytomelatonin: an emerging regulator of plant biotic stress resistance. Trends in Plant Science 26(1):70-82, 2021. (ESI高被引论文；中科院一区；IF=20.5；Top期刊)
5. Zhao, D., Zhang, Y., Ren, H., Shi, Y., Dong, D., Li, Z., Cui, G., Mou, Z., Kennelly, E., Huang, L., Ruan, J., Chen, S., Yu, D., Cun, Y. Multi‐omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum. Journal of Integrative Plant Biology 65(10):2320-2335, 2023. (中科院一区；IF=11.4；Top期刊)
6. Zhao, D.K., Yao, Z., Zhang, J., Zhang, R., Mou, Z., Zhang, X., Li, Z., Feng, X., Chen, S.*, Reiter, R.J.* Melatonin synthesis genes N-acetylserotonin methyltransferases evolved into caffeic acid O-methyltransferases and both assisted in plant terrestrialization. Journal of Pineal Research 71(3), e12737, 2021. (中科院一区；IF=10.3；Top期刊)
7. Lv, Y., Pan, J.J., Wang, H.P., Reiter, R.J., Li, X., Mou, Z.M., Zhang, J.M., Yao, Z.P., Zhao, D.K.*, Yu, D.Q.* Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis. Journal of Pineal Research 70(4), e12736, 2021. (ESI高被引论文；中科院一区； IF=10.3；Top期刊)
8. Zhao, D.K.*, Zhao, Y., Chen, S.*, Kennelly, E.J.* Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis. Natural Product Reports 38(8): 1423-1444, 2021. (封面论文；中科院一区，Q1, IF=11.9；Top期刊)
9. Mou, Z.M., Zhao, D.K.* Gene Rational Design: The Dawn of Crop Breeding. Trends in Plant Science 27(7): 633-636, 2022. (中科院一区；IF=20.5, Top期刊)
10. Zhao, D.K., Shi, X.Q., Zhang, L.M., Yang, D.Q., Guo, H.C., Chen, Y.P., Shen, Y. Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum. Chinese Chemical Letters 28(2): 358–361, 2017. (中科院一区；IF=8.8；Top期刊)
11. Zhao, D.K., Shi, Y.N., Petrova, V., Grace, G.L.Y., Negrin, A., Wu, S.B., D’Armiento, J.M., Lau, C.B.S., Kennelly E.J.* Jaboticabin and related polyphenols from jaboticaba (Myrciaria cauliflora) with anti-inflammatory activity for chronic obstructive pulmonary disease. Journal of Agricultural and Food Chemistry 67(5):1513-1520, 2019. (中科院一区；IF=6.1, Top期刊)
12. Zhao, D.K, Yu, Y., Shen, Y., Liu, Q., Zhao, Z.W., Sharma, R., and Reiter, R.J.* Melatonin synthesis and function: Evolutionary history in animals and plants. Frontiers in Endocrinology 10:249, 2019. (ESI高被引论文；中科院二区；IF=5.2)
13. Li, Y.M., Teng, Z.W., Zhao, D.K.* Plant-derived cross-kingdom gene regulation benefits human health. Trends in Plant Science, 28(6), 626-629, 2023. (中科院一区；IF=20.5；Top期刊)
14. Dong, D., Shi, Y.N., Mou, Z.M., Chen, S.Y., Zhao, D.K.* Grafting: a potential method to reveal the differential accumulation mechanism of secondary metabolites. Horticulture Research 9: uhac050, 2022. (封面论文；中科院1区；IF=8.7；Top期刊)
15. Mou Z.M., Wang H.P., Chen SY. Russal, J.R.*, Zhao, D.K.* Molecular mechanisms and evolutionary history of phytomelatonin in flowering. Journal of Experimental Botany 73(17): 5840-5850, 2022.(中科院一区；IF=6.9；Top期刊)
16. Shi, Y.N., Zhao, Y., Qian, J.X., Dong, Z.Y., Wen, G.S.*, Zhao, D.K.*, Kennelly, E.J.* Aconitum diterpenoid alkaloid profiling to distinguish between the official traditional chinese medicine (TCM) Fuzi and adulterant species using LC-qToF-MS with chemometrics. Journal of Natural Products 84(3): 570-587, 2021. (中科院二区；IF=5.1；Top期刊)
17. He, J., Pu, C.J., Wang, M., Li, Z.H., Feng, T.,* Zhao, D.K.,* Liu, J.K.* Conosiligins A−D, ring-rearranged tremulane sesquiterpenoids from Conocybe siliginea. Journal of Natural Products 83(9), 2743-2748, 2020. (中科院二区；IF=5.1；Top期刊)
18. Zhao, D.K., Li, T., Shen, M., Wang, J.L., Zhao, Z.W.* Diverse strategies conferring extreme cadmium (Cd) tolerance in the dark septate endophyte (DSE), Exophiala pisciphila: evidence from RNA–seq data. Microbiological Research 170: 27–35, 2015. (中科院二区；IF=6.7)
19. Yao Z.P., Zhang, X., Liang, Y.C., Zhang, J.M., Xu, Y., Chen, S.Y., Zhao, D.K.* NtCOMT1 responsible for phytomelatonin biosynthesis confers drought tolerance in Nicotiana tabacum. Phytochemistry 202: 113306, 2022. (中科院二区；IF=3.8)
20. Zhao, D.K., Shen, Y., Shi, Y.N., Shi, X.Q., Qiao, Q., Zi, S.H., Zhao, E.Q., Yu, D.Q.*, Kennelly, E.J.* Probing the transcriptome of Aconitum carmichaelii reveals the candidate genes associated with the biosynthesis of the toxic aconitine-type C19-diterpenoid alkaloids. Phytochemistry, 152 :113-124, 2018. (中科院二区；IF=3.8)
21. Guo, R.H., Guo, C.X., He, D., Zhao, D.K.*, Shen, Y. * Two new C19-diterpenoid alkaloids with anti-inflammatory activity from Aconitum iochanicum. Chinese Journal of Chemistry 35(10): 1644-1647, 2017. (中科院二区；IF=5.4)
22. Mou, Z.M., Zhao, Y., Ye, F., Shi, Y..N., Kennelly, E.J., Chen, S.Y., Zhao, D.K.*. Identification, biological activities and biosynthetic pathway of Dendrobium alkaloids. Frontiers in Pharmacology 12: 605994, 2021. (中科院二区；IF=5.6；Top期刊)
23. Ye, K., Lv, X., Zhang, X., Wei, P., Li, Z.H., Ai, H.L.,* Zhao, D.K.,* Liu, J.K.* Immunosuppressive isopimarane diterpenes from cultures of the endophytic fungus Ilyonectria robusta. Frontiers in Pharmacology 12: 766441, 2022. (中科院二区；IF=5.6；Top期刊)
24. Zhao, D.K., Selosse, M.A., Wu, L.M., Luo, Y., Shao, S.C.*, Ruan, Y.L.* Orchid reintroduction based on seed germination-promoting mycorrhizal fungi derived from protocorms or seedlings. Frontiers in Plant Science 12: 1298, 2021. (中科院二区；IF=5.6；Top期刊)
25. Wang, Q.X., Shao. S.C., Su, Y., Hu, X.L., Shen, Y.*, Zhao, D.K.* A novel case of autogamy and cleistogamy in Dendrobium wangliangii: A rare orchid distributed in the dry-hot valley. Ecology and Evolution 9(22): 12906-12914, 2019. (中科院二区；IF=2.6)
26. Shao, S.C., Wang, Q.X., Beng, K.C., Zhao, D.K.*, Jacquemyn, H.* Fungi isolated from host protocorms accelerate symbiotic seed germination in an endangered orchid species (Dendrobium chrysotoxum) from southern China. Mycorrhiza 30(4): 529-539, 2020. (中科院二区；IF=3.9)
27. Liu, D.D., Sun X.S., Liu L., Shi H.D., Chen S.Y.*, Zhao D.K.* Overexpression of the melatonin synthesis-related gene SLCOMT1 improves the resistance of tomato to salt stress. Molecules 24(8): 1514, 2019. (中科院二区；IF=4.6)
28. Yu, Y., Lv, Y., Shi, Y.N., Li, T., Chen, Y.C., Zhao, D.K.*, Zhao, Z.W.* The role of phyto-melatonin and related metabolites in response to stress. Molecules 23(8): 1887, 2018. (中科院二区；IF=4.6)
29. Zhao, D.K., Shi, Y.N., Zhu, X.Y., Liu, L., Ji, P.Z., Long, C.L., Shen, Y., Kennelly, E.J.* Identification of potential biomarkers from Aconitum carmichaelii, a traditional Chinese medicine, using a metabolomic approach. Planta Medica 84(06/07): 434-441, 2018. (中科院三区；IF=2.7)
30. Zhao, D.K., Ai, H.L., Zi, S.H., Zhang, L.M., Yang, S.C., Guo, H.C., Shen, Y.*, Chen, Y.P., Chen, J.J.* Four new C18–diterpenoid alkaloids with analgesic activity from Aconitum weixiense. Fitoterapia 91: 280–283, 2013. (中科院三区；IF=3.4)
31. Shen, M., Zhao, D.K., Qiao, Q., Liu, L., Wang, J.L., Cao, G.H., Li, T., Zhao, Z.W. * Identification of glutathione S–transferase (GST) genes from a dark septate endophytic fungus (Exophiala pisciphila) and their expression patterns under varied metals stress. PLOS One 10(4): e0123418, 2015. (中科院三区；IF=3.7)
32. Yu, Y., Teng, Z.W., Mou, Z.M., Lv, Y., Li, T., Chen, S.Y., Zhao, D.K.*, Zhao, Z.W.* Melatonin confers heavy metal-induced tolerance by alleviating oxidative stress and reducing the heavy metal accumulation in Exophiala pisciphila, a dark septate endophyte (DSE). BMC Microbiology 21: 40, 2021. (中科院三区；IF=4.2)
33. Zhang, J.M., Yao, Z.P., Zhang, R.J., Mou, Z.M., Yin, H.H., Xu, T.Y., Zhao, D.,* Chen, S.Y.* Genome-wide identification and expression profile of the SNAT gene family in tobacco (Nicotiana tabacum). Frontiers in Genetics, 11:591984, 2020. (中科院三区；IF=3.7)
34. Zhao, D.K., Shi, Y.N., Senthilkumar, H.A., Qiao, Q., Wang, Q.X., Shen, Y.*, Hu G.W.* Enriched networks ‘nucleoside/nucleotide and ribonucleoside/ ribonucleotide metabolic processes’ and ‘response to stimulus’ potentially conferred to drought adaptation of the epiphytic orchid Dendrobium wangliangii. Physiology and Molecular Biology of Plants 25(1):31-45, 2019. (中科院三区；IF=3.5)
35. Liu, W.Y., Zhao, D.K.*, Chen, Y.P., Shen, Y.* Four new C19-diterpenoid alkaloids from the roots of Aconitum ouvrardianum. Journal of Asian Natural Product Research 21(1), 9-16, 2018. (中科院四区；IF=1.7)
36. Duan, X.Y., Zhao, D.K.*, Shen, Y.* Two new bis–C20–diterpenoid alkaloids with anti–inflammation activity from Aconitum bulleyanum. Journal of Asian Natural Product Research 21(4):323-330, 2018. (中科院四区；IF=1.7)
37. Li, G.Q., Zhang, L.M., Zhao, D.K.*, Chen, Y.P., Shen, Y.* Two new C19–diterpenoid alkaloids from Aconitum tsaii. Journal of Asian Natural Products Research 19(5):1–5, 2016. (中科院四区；IF=1.7)
38. Mou, Z., Ye, F., Shen, F.C., Zhao, D.K.* In vitro germination and micropropagation of Aconitum vilmorinianum: an important medicinal plant in China. Phyton-International Journal of Experimental Botany 91(10): 2331-2348, 2022. (中科院四区；IF=1.7)
39. Wang, R.B., Zhang, Z., Yuan, Z.H., Zhang, Y., Mou, Z.M., Zhao, D.K.* Holcoglossum× kunmingense hybr. nat. nov. (Orchidaceae: Aeridinae) from Yunnan, China. Phytotaxa, 2022, 573(1): 131-139.(中科院四区；IF=1.1)
40. Lv, Y., Shen, Y., Shi, Y., Shen, F., Chen, Y., Zi, S., Zhu, Z., Kennelly, E. J., Zhao, D.K* Root-endophytic fungi diversity of Fuzi (Aconitum Carmichaelii) and their anti-fungal activity. Applied Ecology and Environmental Research 17(6):15289-15300, 2019. (中科院四区；IF=0.7)
