李艳，女，博士，1983年9月生，云南人，云南省中青年学术带头人、云南省万人计划青年拔尖人才。现任尊龙凯时生物资源保护与利用国家重点实验室研究员，博士生导师。
主要从事家养动物起源和适应性进化遗传机制方面的研究。先后承担完成了国家自然科学基金集成项目、面上项目、地区项目、青年项目，科技部国家重点研发项目、青藏高原二次科考项目，中科院先导专项等20余项；在国内外核心刊物上发表学术论文38篇，其中SCI刊物上发表36篇。
在解析家养动物的驯化起源历史及优质性状的遗传基础方面取得了突出成绩，主要包括以下几个方面：
（1）围绕代表性高海拔畜禽品种，针对种质资源结构和环境适应机制科学问题，利用前沿群体多组学技术手段，开展了长期系统性研究，揭示了高山特色珍稀品种独龙牛特异的染色体融合及其对肉质性状的影响，有助于保护和利用这一优秀种质资源，为国家种业储备和应用提供支持。同时，也加深了对肌肉发育与维持等基本生命科学问题的理解，为相关前沿领域的研究提供了科学依据。
（2）阐明藏獒连续匀质、藏鸡独立分离的种质资源遗传结构特征及各自的缺氧适应机制，以及不同通路在不同高海拔畜禽进化过程中的遗传特征，梳理高原适应性形成机制的多样性，归纳高海拔畜禽动物共性遗传特征，即遗传渗透是快速形成高海拔适应性进化的有效途径，趋同进化是其共性进化规律。
（3）揭示温顺行为转变的调控靶点，为性情的选育和优化提供了方向，有利于推动高海拔地方品种的规模化养殖。
（4）在高海拔地方特色产业扶持方面开展了持续探索：开发独龙牛种质资源分子鉴定技术，主持制定独龙牛分子鉴定云南省地方标准，帮助当地企业优化核心育种群，合作承担兴边富民项目；开发藏獒种质资源分子鉴定技术，帮助当地企业新增利润百余万元，实现成果转化 370 余万元，为科技推动现代种业高质量发展写下鲜明注脚。
联系方式
E-mail: liyan0910@cqlty.com
学历
l2002.9－2006.7: 中山大学生命科学学院，生物技术及应用基地班学习，获理学学士学位
l2006.9－2008.7: 中山大学，生物化学与分子生物学专业，获理学硕士学位
l2008.9－2012.7: 尊龙凯时，遗传学专业，获遗传学专业博士学位。
近十年主持或承担的科研项目
l2015-2017：国家基金委青年项目: 藏獒在高海拔渐变复杂环境下适应性进化的遗传机制，项目负责人，经费24万元
l2018-2019：国家基金委重大研究计划集成项目: 多组学视角下家犬行为微进化的基因相互作用机制，课题骨干，经费132.45万元
l2018-2023：中国科学院战略性先导科技专项（A类）子子课题: 马属动物群体历史和局部适应机制研究，子子课题负责人，经费115万元
l2019-2022：国家基金委地区项目: 组学视角下解析大额牛优秀肉质性状的遗传基础，项目负责人，经费39万元
l2019-2024：科技部第二次青藏高原综合科学考察研究子课题: 藏南及周边地区大额牛基因组遗传特征及种质资源概况，子课题负责人，经费100万元
l2021-2024：国家基金委面上项目: 遗传渗透潜在影响下的中国固有家马品种驯化历史及地理分布格局成因，项目负责人，经费58万元
l2021-2026：科技部国家重点研发计划课题: 特色牛抗逆及肉质优异种质资源精准鉴定，子课题负责人，经费265万元
l2022-2023：云南省地方标准重点项目: 独龙牛种质特征遗传分子鉴定技术规程，项目负责人，经费10万元
近十年发表主要学术论文
1. Guoliang Lin#, Zhiru Huang#, Tingsong Yue#, Jing Chai#, Yan Li#, Huimin Yang, Wanting Qin, Guobing Yang, Robert W. Murphy, Ya-ping Zhang*, Zijie Zhang*, Wei Zhou*, Jing Luo*. 2024. Puzzle Hi-C: an accurate scaffolding software. PLoS ONE, 19: e0298564.
2. Jiyang Wang, Min Deng, Jiaona Yang, Xiaojuan Zhou, Peng Yang, Yan Li*, Guimin Zhang*. 2023. FOXN4 affects myocardial ischemia-reperfusion injury through HIF-1αMMP2-mediated ferroptosis of cardiomyocytes. Cellular and Molecular Biology, 69: 214-225
3. Jingjing Gu*, Sheng Li*, Bo Zhu, Qiqi Liang, Bin Chen, Xiangwei Tang, Chujie Chen, Dong-Dong Wu*, Yan Li*. 2023. Genetic variation and domestication of horses revealed by 10 chromosome-level genomes and whole-genome resequencing. Molecular Ecology Resources, 23: 1656-1672.
4. Li Yan#,*, Sheng Wang#, Zhe Zhang#, Jing Luo#, Guo Liang Lin#, Wei-Dong Deng#, Zhifan Guo#, Feng Ming Han, Li-Li Wang, Jie Li, Shi-Fang Wu, He-Qun Liu, Sheng He, Robert W. Murphy, Zi-Jie Zhang, David N Cooper, Dong-Dong Wu, Ya-Ping Zhang*. 2023. Large-scale chromosomal changes lead to genome-level expression alterations, environmental adaptation and speciation in the gayal (Bos frontalis). Molecular Biology and Evolution, 40: msad006.
5. Shao Yong#,*, Wang Xiao-Bo#, Zhang Mei-Ling#, Liu Yan#, Wang Sheng, Zhang Bao-Lin, Yang Min-Min, Yang Ming-Hai, Jia Ting, Pu Tian-Chun, Lu Yan, Liu He, Xu Zhe, Li Bo, Liu Ning, Onsongo Violet Magoma, Wu Dong-Dong, Zhang Cheng-Lin*, Ruan Jue* & Li Yan*. 2022. Long-read genome sequencing provides molecular insights into scavenging and societal complexity in spotted hyena Crocuta crocuta. Molecular Biology and Evolution, 39: msac011.
6. Li Yan*, Wu Dong-Dong. 2021. Finding unknown species in the genomes of extant species. Journal of Genetics and Genomics, 48: 867-871.
7. Nanaei1 Hojjat-Asadollahpour, Esmailizadeh Ali*, Mehrgardi Ahmad-Ayatollahi, Han Jianlin, Wu Dong-Dong, Li Yan*, Zhang Ya-Ping*. 2020. Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony. BMC Genomics, 21: 496.
8. Wang Ming-Shan#, Wang Sheng#, Li Yan#, Jhala Yadvendradev#, Thakur Mukesh#, Otecko Newton O., Si Jing-Fang, Chen Hong-Man, Shapiro Beth*, Nielsen Rasmus*, Zhang Ya-Ping*, Wu Dong-Dong*. 2020. Ancient hybridization with an unknown population facilitated high altitude adaptation of canids. Molecular Biology and Evolution, 37: 2616-2629.
9. Li Ming-Li#, Tang Hui#, Shao Yong, Wang Ming-Shan, Xu Hai-Bo, Wang Sheng, Irwin David M., Adeola Adeniyi C., Zeng Tao, Chen Luonan#,*, Li Yan#,*, Wu Dong-Dong#,*. 2020. Evolution and transition of expression trajectory during human brain development. BMC Evolutionary Biology, 20: 72.
10. Zhang Zhe, Khederzadeh Saber, Li Yan*. 2020. Deciphering the puzzles of dog domestication. Zoological Res, 41: 97-104.
11. Ma Xi-Yao#, Ning Tiao#, Adeola Adeniyi C.#, Li Jie#, Esmailizadeh Ali, Lichoti Jacqueline K., Agwanda Bernard R., Isakova Jainagul, Aldashev Almaz A., Wu Shi-Fang, Liu He-Qun, Abdulloevich Najmudinov Tojiddin, Afanasevna Manilova Elena, Ibrohimovich Khudoidodov Behruz, Adedokun Rahamon Akinyele Moshood, Olaogun Sunday Charles, Sanke Oscar J., Mangbon Godwin F., Chen Xi, Yang Wei-Kang, Wang Zhe, Peng Min-Sheng, Ommeh Sheila C.*, Li Yan*, Zhang Ya-Ping*. 2020. Potential dual expansion of domesticated donkeys revealed by worldwide analysis on mitochondrial sequences. Zoological Res, 41: 51-60.
12. Li Yan, Wang Ming-Shan, Otecko O Newton, Wang Wen, Shi Peng, Wu Dong-Dong, Zhang Ya-Ping. 2017. Hypoxia potentially promotes Tibetan longevity. Cell Res, 27: 302-305.
13. Kader A#, Li Y#, Dong KZ, Irwin DM, Zhao QJ, He X, Liu JF, Pu YB, Gorkhali NA, Liu XX, Jiang L, Li XC, Guan WJ, Zhang YP, Wu DD*, Ma YH*. 2015. Population variation reveals independent selection towards small body size in Chinese Debao pony. Genome Bio. Evol, 8:42-50.
14. Wang MS*, Li Y*, Peng MS*, Zhong L, Wang ZJ, Li QY, Tu XL, Dong Y, Zhu CL, Wang L, Yang MM, Wu SF, Miao YW, Liu JP, Irwin DM, Wang W, Wu DD, Zhang YP. 2015. Genomic analyses reveal potential independent adaptation to high altitude in Tibetan chickens. Mol Biol Evol, 32:1880-1889.
15. Wu DD*, Ye LQ*, Li Y*, Sun YB, Shao Y, Chen CY, Zhu Z, Zhong L, Wang L, Irwin DM, Zhang YE, Zhang YP. 2015. Integrative analyses of RNA-editing, alternative splicing and expression of young genes in human brain transcriptome by deep RNA-sequencing. J Mol Cell Biol, 7:314-325.
16. Li Y, Wang GD, Wang MS, Irwin DM, Wu DD, Zhang YP. 2014. Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis. Genome Biol Evol, 6:3115-3121.
17. Li Y, Wu DD, Boyko AR, Wang GD, Wu SF, Irwin DM, Zhang YP. 2014. Population variation revealed high altitude adaptation of Tibetan Mastiffs. Mol Biol Evol, 31(5): 1200-1205.
18. Liu HQ*, Li Y*, Irwin DM, Zhang YP, Wu DD. 2014. Integrative analysis of young genes, positively selected genes and IncRNAs in the development of Drosophila melanogaster. BMC Evol Biol, 14:241.
19. Wu DD*, Wang X*, Li Y*, Zeng L, Irwin DM, Zhang YP. 2014. “Out of pollen” hypothesis for origin of new genes in flowering plants: study from Arabidopsis thaliana. Genome Biol Evol, 6(10):2822-2829.
20. Li Y, vonHoldt BM, Wang GD, Reynolds A, Boyko AR, Wu DD, Zhang YP. 2013. Artificial selection on brain expressed genes during the domestication of dog. Mol Biol Evol, 30: 1867-1876.
